Zopiclone (Imovane) is indicated for the short-term therapy and symptomatic reduction of insomnia characterized by issue in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone should normally not exceed 7-10 consecutive days. Use for more than 2-3 consecutive weeks requires complete re-evaluation of the affected person. Prescriptions for zopiclone ought to be written for short-term use (7-10 days) and it should not be prescribed in portions exceeding a 1-month supply.
The use of hypnotics should be restricted for insomnia where disturbed sleep ends in impaired daytime functioning.
Dosage and administration:
Imovane should solely be taken when you are in a position to get a full night time’s sleep (7 to 8 hours) earlier than you should be lively once more.
The commonplace grownup dose of zopiclone is one tablet simply earlier than you go to bed.
This medicine ought to be taken in a single consumption and not readministered throughout the same night time.
If you may be over sixty five years of age the dose is half a pill taken just before you go to bed.
If you’ve a liver or kidney drawback, the usual recommended dose is half a pill taken just before you go to bed.
Overdosage:
Signs and signs:
Overdose by zopiclone tablets is often manifested by varying levels of central nervous system melancholy ranging from drowsiness to coma in accordance with the amount ingested. In mild circumstances, symptoms include drowsiness, confusion, and lethargy; in more extreme instances, symptoms could include ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory melancholy, and coma. Overdose shouldn’t be life threatening unless combined with different CNS depressants, including alcohol. Other risk elements, such as the presence of concomitant illness and the debilitated state of the patient, might contribute to the severity of signs and very hardly ever can outcome in fatal consequence.
In voluntary or accidental circumstances of zopiclone overdosage involving doses as much as 340 mg, the principal results reported were prolonged sleep, drowsiness, lethargy and ataxia.
Recommended therapy:
Symptomatic and supportive therapy in adequate scientific setting is recommended, consideration must be paid to respiratory and cardiovascular capabilities. Gastric lavage or activated charcoal is only useful when carried out soon after ingestion.
Hemodialysis is of no worth because of the giant quantity of distribution of zopiclone. Flumazenil may be a useful antidote; however, flumazenil administration might contribute to the looks of neurological symptoms (agitation, nervousness, convulsionsand emotional lability). Intravenous fluids should be administered as wanted.